Cardio Tips: Nitric Oxide and Heart Disease

In almost every country Coronary Heart Disease or one or more forms of Cardiovascular Disease (CVD) is listed in the top 5 leading causes of death.

Over a Billion people worldwide suffer from one or more forms of Cardiovascular Disease which include all the diseases of the heart and circulation including coronary heart disease, angina, heart attack, congenital heart disease, and stroke.

Top 10 leading causes of death

Is Heart Disease A Lifestyle Disease?

Heart Disease can be called a lifestyle disease that is caused by poor eating habits, smoking, obesity, high blood pressure, high blood sugar levels, lack of physical activity, stress, lack of sleep and pollution.

Arterial Inflammation

Newer scientific research has now shown that the real cause of heart disease is arterial inflammation. The processed foods we eat, aging in general, stress, and pollution cause an inflammatory reaction on a cellular level in the arterial wall.

Inflammation is the body’s protective response to irritation or injury. The same healing mechanism that helps a paper cut heal is the same response inside the arterial wall that’s clogging our arteries. It’s an immune response.

Nitric Oxide To The Rescue

It turns out, many lives could be saved from heart attacks, strokes, and cardiovascular disease if more people were to discover the miracle properties of Nitric Oxide (NO).

Nitric Oxide Widens Your Arteries And Increases Blood Flow To Your Body's Cells

So What Is Nitric Oxide (NO), Anyway?

Some people think nitric oxide is the laughing gas at the dentist clinic (That's nitrous oxide by the way). Some people think nitric oxide is the fuel racing car drivers use to make their cars go faster, while others think it's the key ingredient in dynamite. But it's neither. Nitric oxide is derived naturally from arginine — more on that amino acid in a minute.

Nitric Oxide (NO) is regarded as the most significant molecule in the body. It influences the functioning and well-being of the entire body.

A Nobel Prize In Medicine

Our scientific understanding of this important 'miracle molecule' for fighting cardiovascular disease stepped up back in 1998 when three American scientists were awarded the Nobel Prize in Medicine for their discovery that the body uses the gas molecule Nitric Oxide (NO) to relax and widen blood vessels — a finding that is helping millions and millions of people in the prevention and treatment of heart disease.

Here's What Nobel Laureate In Medicine, Dr. Louis J. Ignarro Said On Nitric Oxide:

Louis Ignarro, Ph.D., Nobel Laureate in Medicine (1998) and author 'No More Heart Disease' 

Dr. Louis J. Ignarro

"Though NO's structure is simple, nitric oxide is now regarded as the most significant molecule in the body, absolutely crucial to your well-being. I am convinced that the nitric oxide can age-proof your cardiovascular system, keeping it much fitter than your chronological age would indicate." "Repairing the damage wrought by cardiovascular disease without risky and often ineffective surgery had long been considered impossible. I was awarded the noble prize in Medicine for making that thinking obsolete. Now we know we can reverse cardiovascular impairment naturally – with the body's internally manufactured 'wonder drug' nitric oxide."

Cardiovascular Age-Proofing

Nitric Oxide Production In The Endothelium

The nitric oxide the body produces influences the function of virtually every bodily organ, including the heart, lungs, liver, kidneys, stomach and sexual organs. It is manufactured in the body in the endothelium — the layer of cells lining the interior surface of blood vessels that separate the blood from the smooth muscle walls.

Unclogging Arteries And Regulating Blood Pressure

In a healthy endothelium (inner wall of a blood vessel), nitric oxide will keep blood vessels pliable and elastic, free of the plaque that causes heart attack and stroke. It maintains normal blood pressure by relaxing arteries, helping them dilate (open up) and to keep blood flowing smoothly. It keeps the platelets and white blood cells calm and prevents them from sticking to the vessel wall like Velcro.

Preventing Oxidation And Suppressing Atherosclerosis

Nitric oxide prevents oxidation, slows plaque growth, suppresses atherosclerosis (build-up of cholesterol, fat, and calcium) in your arteries, and may melt away ¹ ² ³ ⁴ existing plaque. 

What's more, as we age our body becomes less efficient at producing nitric oxide by up to 85%. Your arteries become stiffer and blood flow is forced through a smaller space raising blood pressure, a major risk factor for heart disease, heart attack, and stroke.

As You Age You Lose Up to 85% of Nitric Oxide. This Leads to Disease and Aging Infirmities

To offset this you can increase nitric oxide through exercise and a healthy NO-friendly diet. But given our appetite for low nutrient junk food and leading a sedentary lifestyle, an increasingly popular way is by supplementing using the amino acids L-Arginine and L-Citrulline in synergy with numerous other natural nutrients to efficiently boost the body's levels of nitric oxide production.

Repair Cardiovascular Impairment Naturally

Medically published clinical studies have shown scientifically that Nitric Oxide created by arginine will do the following:

  • Widen the blood vessels (increasing blood flow throughout the body)
  • Soften the blood vessels (reversing the hardening of the arteries)
  • Relax the blood vessels (overcoming most high blood pressure)
  • Inhibit and melt away plaque (preventing and reversing atherosclerosis, coronary artery disease, heart attack, stroke and peripheral artery disease)
  • Decreases blood pressure
  • Improves outcome after bypass surgery
  • Lowers elevated serum triglyceride levels
  • Improves diabetes and reverses damage caused by diabetes
  • Improves pituitary responsiveness and modulates the hormonal control
  • Improves asthma improves
  • Irritable bowel syndrome
  • Improves osteoporosis
  • Reduces ulcers
  • Improves the outcome of cancer treatment
  • Improves Alzheimer's
  • Improves long-term and short-term memory and cognitive functions
  • Improves prostate function
  • Improves sexual function, libido, performance, and satisfaction in both men and women
  • Improves renal (kidney) function
  • Alleviates cirrhosis, helps to detoxify the liver, and liver malfunction can occur as a result of arginine deficiency
  • Alleviates obesity and facilitates weight loss (stimulating the release of human growth hormone from the pituitary gland)
  • Improves muscle performance
  • Increases human growth hormone (anti-aging)
  • Increases your energy levels to a more youthful state
  • How Arginne = Nitric Oxide

    Proteins are a key building block material that is crucial for the maintenance of the body's tissue, the formation of muscles and organs, wound healing, energy and the regulation and movement of oxygen and nutrients throughout the body.

    When you eat protein-rich foods like red meat, fish, chicken, tofu, egg whites, and nuts, your digestive enzymes in your small intestines break them down into amino acid compounds. L-arginine and L-citrulline are two of them.

    How Does L-Arginne Work?

    Arginine is a naturally produced amino acid that enhances blood flow and improves the efficiency of the endothelial cells because it is converted to NO in the body. It also helps in the prevention of atherosclerosis (blockage of the arteries).

    When arginine is consumed in foods (red meat, fish, chicken, beans, soy, nuts) or taken in supplement form, it makes its way into the bloodstream and circulates throughout the body. As it enters the endothelial cells that line the smooth muscle walls of blood vessels, an enzymatic reaction occurs that converts arginine to nitric oxide. As the levels of arginine rise in the body so do your production of nitric oxide, which in turn can have a dramatic and positive effect on your cardiovascular health.

    Today there are over 100,000 written and published clinical research studies attesting to the fact that the amino acid l-arginine enables your body to regulate all aspects of its cardiovascular function.

    How Does L-Citrulline Work?

    L-citrulline is an amino acid and is closely related to L-arginine. It promotes energy, stimulates the immune system, and detoxifies ammonia, which damages cells. It is found in protein-rich foods and watermelon rinds (not as much in the red stuff).

    In your body, L-citrulline is converted into L-arginine, which in turn significantly increases the production of nitric oxide.

    But here's the thing, it is the synergy between L-arginine and L-citrulline and key antioxidants that create dramatic increases in your body's NO production.

    What Other Experts Are Saying

    Joe Prendergast, Ph.D., co-author 'The Arginine Solution' (with Woodson Merrell, MD) "I believe that L-Arginine is the single most important discovery in the preventing heart disease that I have seen during the course of my medical career. Of course, there are many treatments for heart disease, but I haven't seen anything as effective." "We cannot ignore the power of L-Arginine anymore. Heart Disease is the number one killer in our country for both men and women. The main factors are arteriosclerosis, hardening of the arteries, and atherosclerosis, buildup on the arterial lining. L-Arginine reverses both problems."
    Jonathan S. Stamler, M.D., Practicing Endocrinologist "In the field of medicine and health, it is one of the revolutions of our time: The discovery that the amino acid arginine may be a "Magic Bullet" for the cardiovascular system. Now, as the evidence mounts, including research that won the Nobel Prize in Medicine, more and more scientist and doctors see the extraordinary health benefits of increasing arginine intake. A virtual arterial cleanser, arginine helps eliminate blockage and maintain blood flow."
    Robert Fried, Ph.D., co-author 'The Arginine Solution' (with Woodson Merrell, MD) "It does everything, everywhere. You cannot name a major cellular response or physiological effect in which [nitric oxide] is not implicated today. It's involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, the function of blood cells, the immune system, even how fingers and arms move."
    Arginine Nitric Oxide: No more heart disease & strokes

    NO More Heart Disease: How Nitric Oxide Can Prevent--Even Reverse--Heart Disease and Strokes by author and Nobel Laureate in Medicine, Dr. Louis J. Ignarro, is a very informative and lifesaver guide on how to reverse heart disease. I highly recommend getting yourself a copy. It's a book that everyone who wants to improve their heart health should read. Dr. Ignarro clearly explains Nitric Oxide (NO) vital role in human health and reducing the risk of heart disease.

    Dr. John Cooke, M.D., Ph.D., Director of Vascular Medicine at Stanford University and author 'The Cardiovascular Cure' "This book will introduce you to the magic that is inside your blood vessels. It comes in the shape of the molecule, one of the simplest molecules found in nature. This molecule is Nitric Oxide, or NO, a substance so powerful that it can actually protect you from a heart attack and stroke. Best of all, your body can make it on its own. NO is your body's own built-in, natural protection against heart disease."

    Guess What? Nitric Oxide Can Be Activated By Supplementation!

    While you can get some L-arginine and L-citrulline from NO-friendly foods, they do not provide it in sufficient amounts. You need the power of NO-boosting supplements, especially as you age and your body becomes less efficient at producing nitric oxide.

    However, it is hard to find a well-formulated all-natural product that is created by this Nobel Prize in Medicine winning technology.

    The good news is, some of the best-made heart-healthy formulas out there can be discovered through "word of mouth." 


    1. 1
      Harrison DG, Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am J Cardiol 1995 Feb 23;75(6):75B-81B. 
    2. 2
      Minor RL Jr, Myers PR, et al. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 1990 Dec;86(6):2109-2116. 
    3. 3
      Andrews TC, Raby K, et al. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Circulation 1997 Jan 21;95(2):324-328. 
    4. 4
      Stroes ES, Koomans HA, et al. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet 1995 Aug 19;346(8973):467-471.

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    About the author

    Ollie Relfe

    Hello, my name is Ollie. I am an home business entrepreneur, coach and blogger living near Brighton, UK. This is my blog, where I post my photos, news about home business streams, share resources and marketing tips. I also help busy people to detox, lose weight & achieve optimal health with a fast easy certified organics program. You can reach out to me here

    About the author

    Ollie Relfe

    Hello, my name is Ollie. I am an home business entrepreneur, coach and blogger living near Brighton, UK. This is my blog, where I post my photos, news about home business streams, share resources and marketing tips. I also help busy people to detox, lose weight & achieve optimal health with a fast easy certified organics program. You can reach out to me here

    PS: The cost of living crisis is real and getting worse.

    I show people how we are beating the cost of living crisis by earning enough money to make their bank account bigger and their bills smaller. If you'd ever like to know, I'll be glad to show you.